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Author

Alice Buonfiglioli

2 papers indexed here

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Open access Oct 2026

Parkinson’s disease genetic risk converges on Lewy body pathology-associated microglial states

Parkinson's disease (PD) and related -synucleinopathies are defined by the spread of Lewy body (LB) pathology across vulnerable brain regions, yet how substantia nigra (SN) myeloid cells respond remains unresolved. Using SOX10-based oligodendrocyte depletion and CD11b-based myeloid enrichment, we profiled 169,799 brain...

Raphael Kübler, Daniele Mattei, J. O. Narcís et al. · 0 citations
Open access Aug 2026

Cholesterol Dysregulation in APOE4 Astrocytes Promotes α-Synuclein Pathology in miBrains

An iPSC-based 3D model that integrates neurons, glia, myelin, and cerebrovascular cells into a human brain-like tissue (“miBrain”) is developed and establishes a robust model for investigating protein inclusions in human iPSC-derived brain tissue.

Louise A. Mesentier-Louro, Camille Goldman, Sebastian Gaese et al. · 2 citations

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