Open access
Oct 2026
A heritability-optimized method for functional prioritization of rare coding variants in complex traits
Population sequencing studies are uncovering millions of missense rare variants (RVs) implicated in the ‘missing heritability’ of complex diseases, yet distinguishing functional from neutral variation remains challenging. Here we present rare variant heritability-optimized scores (RovHer), a heritability-optimized meth...
Keona Pang, Nazia Pathan, Ann Le et al.
· Nature Genetics · 0 citations