Author

Alicia M. Kirk

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Open access Sep 2026

Structural and Functional Characterisation of a Metagenome‐Derived CYP108D18 Reveals an Unusual Dioxygen‐Bound State and Selective Hydrocarbon Hydroxylation

ABSTRACT Cytochrome P450 enzymes form a large superfamily of monooxygenases capable of oxidising diverse substrates. Among them, members of the CYP108 family are recognised for their role in monoterpenoid oxidation. In this study, we report the identification and characterisation of a new CYP108 family member, CYP108D1...

S. Kundral, Peter D. Giang, Alicia M. Kirk et al. · Microbial Biotechnology · 0 citations

Open access Jul 2026

Mechanism for Aromatic Nitration Catalyzed by Cytochrome P450 Enzymes from Rufomycin Biosynthesis

During the biosynthesis of the peptide antibiotic rufomycin, the cytochrome P450 (P450) enzyme RufO catalyzes the aromatic nitration of a tyrosine residue in a ribosomal pentapeptide that serves as a precursor for nonribosomal peptide synthesis. To understand the mechanism of this unusual P450-mediated reaction, a se...

A. M. Kirk, Jemma Gullick, Yong-Wei Zhao et al. · Journal of the American Chem... · 0 citations