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Author

Alina Kazakova

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Review Open access Oct 2026

The CXCL12/CXCR4 axis in breast cancer-associated fibroblasts: a transcriptome analysis and systematic literature review

Cancer-associated fibroblasts (CAFs) represent a pivotal component of the breast cancer microenvironment. In a paracrine model, CAFs secreted the chemokine CXCL12 (SDF-1α), which bound to CXCR4 and activated the PI3K/AKT and MAPK signaling pathways, stimulating their migration and invasion. TGF-β1 induces myofibrob...

Sergey Vladimirov, David Sergeevichev, M. Bogachek et al. · 0 citations
Open access Sep 2026

Stromal Remodeling of the Cytokine Secretome Reveals a Chemokine Core Across Breast Cancer and Glioma 3D Cell Culture Models

Mounting evidence indicates that the tumor microenvironment plays a decisive role in cancer progression. However, the quantitative assessment of how individual stromal components contribute to cytokine secretion in 3D models remains poorly understood, especially when comparing tumours of different origins. The developm...

David Sergeevichev, A. Leonteva, Alina Kazakova et al. · 0 citations
Open access Jul 2026

Reconstructing the glioblastoma microenvironment in heterotypic 3D spheroids: a multicellular model to study tumor-stromal crosstalk

These heterotypic 3D spheroid models offer a stroma-enriched, reproducible platform for the analysis of stromal contributions to glioma progression and for exploratory preclinical evaluation of therapeutic strategies.

Y. Nikitina, Alina Kazakova, A.A. Leonteva et al. · 0 citations

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