Open access
Oct 2026
Catabolism of extracellular glutathione is a driver of metastasis formation
Metastasizing cancer cells require metabolic plasticity to adapt to the microenvironment of the target organ. Analyzing metabolites in interstitial fluids, we found that the liver microenvironment is devoid of cystine but contains high concentrations of glutathione (GSH). Detailed mechanistic analysis revealed that can...
Felix C. E. Vogel, F. Röhrig, Danny Schilling et al.
· bioRxiv · 0 citations