Author

Alise Zagare

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Review Open access Jul 2026

Brain organoids in Parkinson's disease drug development: Human-specific models for translational discovery.

This review summarizes drug screening studies in midbrain organoids across genetic, toxin-based, and α-synuclein preformed fibril models and critically assess current limitations and outline how artificial intelligence integration and assembloid platforms are advancing organoid-based drug discovery towards regulatory a...

Alise Zagare, J. Jarazo, J. Schwamborn · Drug Discovery Today · 1 citation

Open access Aug 2026

LRRK2-G2019S impairs astrocyte differentiation and triggers a senescence-like phenotype in Parkinson’s disease models

Data show that LRRK2-G2019S impairs astrocyte specification and predisposes to a senescent phenotype, which contributes to the acquisition of a senescent-like phenotype in Parkinson’s disease patients.

Lisa M. Smits, S. Magni, K. Grzyb et al. · npj Parkinson's Disease · 0 citations