Author

Alison M. Goate

2 papers indexed here

We haven’t gathered this author’s papers yet. Follow them and we’ll fetch their work.

Not the right person? Other researchers publish under this name.

Open access Sep 2026

Human iPSC models reveal APOE4-induced microglial remodeling and extracellular vesicle dysregulation in AD pathogenesis

Abstract The apolipoprotein E ε4 ( APOE4 ) allele is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD), yet the mechanistic underpinnings by which it alters human microglial function remain poorly understood. Here, we utilize CRISPR/Cas9-engineered isogenic human induced pluripotent stem cell-de...

T. Ikezu, Y. You, Son Nguyen et al. · Research Square · 0 citations

Open access Aug 2026

APOE3 and APOE4 human astrocytes differentially modulate Alzheimer’s disease pathology and microglial responses in chimeric mice

A chimeric model of AD is generated by transplanting isogenic APOE3 or APOE4 human induced pluripotent stem cell-derived astrocyte progenitors into neonatal AD mice and highlighting a role for human astrocytes and APOE-dependent astrocyte functions in modulating AD-related pathology.

Joan Cruz-Sesé, Marta Mirón-Alcala, Maria Alfonso-Triguero et al. · Cell Reports · 0 citations