Alla S. Kostyukova

Structure of the actively growing actin filament pointed end facilitated by Leiomodin-2.

Cardiac contraction depends on synchronized interactions between myosin-based thick filaments and actin-based thin filaments (TFs). Precise regulation of TF length is vital for cardiac function, as any alteration in length leads to severe myopathies. Actin filaments form the backbone of the TF and have two unequal ends...