ABSTRACT Detecting metabolic dysfunction-associated steatohepatitis (MASH) before fibrosis develops remains a major challenge. We used a longitudinal streptozotocin/high-fat diet (STAM/HFD) mouse model to identify microbial and metabolic features that emerge before histological MASH onset. Integrative 16S rRNA and unta...
Stephany Flores Ramos, Kelly A. Fogelson, V. Muti et al.· mSystems· 0 citations
Overall, this work establishes pyoverdines as metallophores involved in La uptake, re-framing them from strictly iron-scavenging siderophores to dual-purpose metallophores with Ln-binding activity.
Kalen Rasmussen, Jonathan Michael, A. Benson et al.· bioRxiv· 0 citations
Iron is widely considered the first metallocofactor, evolving as iron-sulfur clusters in early life. While iron-chelating siderophores have been widely characterized across microbial life, the lanthanide-chelating metallophore, methylolanthanin, has only recently been described in Methylobacterium extorquens AM1. Methy...
Alexa M. Zytnick, Marquis T. Yazzie, Tashi C. E. Liebergesell et al.· bioRxiv· 0 citations
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