Allen B. Reitz

TDP-43 overexpression induces cellular dysfunction and ALS-associated transcriptional changes

This stable, inducible TDP-43 overexpression model and its associated transcriptomic dataset provide a versatile platform for ALS and other TDP-43 proteinopathy research, enabling the investigation of molecular drivers of TDP-43 dysfunction, the identification of potential disease-relevant pharmacological targets, and...