Author

Allison D. Ebert

2 papers indexed here

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Open access Oct 2026

Astrocyte SMN Restoration and Forskolin Treatment Improve SMA Synaptic Pathology.

OBJECTIVE Early phenotypic presentation of central afferent synapse dysfunction within patients with spinal muscular atrophy (SMA) represents a key target for therapeutic development; however, the underlying disease mechanisms remain unresolved. By further investigating motor neuron synapse and peri-synaptic astrocyte...

Emily Welby, Xiao-Jie Liu, Melinda Wojtkiewicz et al. · Annals of Neurology · 0 citations

Review Open access Sep 2026

The Role of the Mammalian Target of Rapamycin in Microglial Phenotypic Polarization

Highlights What are the main findings? mTOR signaling regulates microglial phenotypic plasticity by coordinating many cellular processes including metabolic reprogramming, inflammatory mediator production, and cytoskeletal remodeling. mTORC1 generally amplifies pro-inflammatory microglial responses, whereas mTORC2 appe...

Kaitlyn J. Partridge, Allison D. Ebert · Cells · 0 citations