α2δ-2 mediates coupling of presynaptic calcium entry to vesicle release in hippocampal parvalbumin-expressing interneurons
The α2δ family of auxiliary voltage-gated calcium channel (VGCC) subunits have critical but incompletely understood roles in brain function. Parvalbumin-positive (PV+) interneurons in the hippocampus highly express the α2δ-2 isoform, and mice lacking α2δ-2 exhibit spontaneous seizures. Thus, we examined PV+ neuron-medi...