Author

Alma L. Burlingame

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Open access Sep 2026

Structural basis of a SWI/SNF-associated transcription pre-initiation complex.

The mating type switching/sucrose non-fermenting (SWI/SNF) chromatin remodeling complex removes and repositions nucleosomes at promoters for the initiation of transcription. Though long thought to function independently, we find that SWI/SNF is an integral component of the transcription machinery. SWI/SNF associates wi...

S. Nagai, Chun Yang, Dong-Hua Chen et al. · Cell · 1 citation

Open access Sep 2026

Targeting prostaglandin catabolism via topical nanotherapy rescues vision in ischemic optic neuropathy

Ischemic optic neuropathy is a leading cause of acute vision loss and currently lacks effective therapy. Here, we identify 15-hydroxyprostaglandin dehydrogenase (15-PGDH), the key enzyme responsible for prostaglandin degradation, as a metabolic checkpoint in ischemic optic neurodegeneration. Analysis of human ischemic...

Shweta Modgil, Rusiou Hsu, M. Shariati et al. · Neurotherapeutics · 0 citations

Open access Aug 2026

Defining the Early Response of Oligodendrocyte-Lineage Cells to Traumatic CNS Axonal Injury.

Injured central nervous system axons rarely regenerate or remyelinate efficiently. Oligodendrocyte (OL) -lineage cells influence both processes, yet their early response to axonal injury remains incompletely defined. Using an optic nerve crush model in male and female mice, we profiled acute OL-lineage responses over t...

Yu Wu, Xiaoyun Ding, Jiaxing Li et al. · Journal of Neuroscience · 0 citations