Alma Y. Wu

Specific exclusion of conjugative plasmids from the gut microflora

It is shown that this engineered ‘probiotic plasmid’ prevents invasive AMR plasmids from entering bacterial populations in vitro and in vivo, in the mouse gut, and offers a promising new strategy to control invasive AMR plasmids and prevent AMR acquisition in high-risk settings, such as in hospitals or AMR-endemic regi...