Author

Alonso Heredia

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Open access Oct 2026

Cell-based therapy for HIV brain reservoirs: glial progenitors delivering broadly neutralizing antibodies

Abstract Objective Despite the success of combination antiretroviral therapy (cART) in suppressing HIV replication, viral reservoirs persist in a latent state in resting memory CD4+ T-cells, lymphoid tissue and spleen, as well as in glia within the central nervous system (CNS), necessitating lifelong treatment. Persist...

Lorissa I. McDougall, A. Abbasi, Mohammad M. Sajadi et al. · NeuroImmune Pharmacology and... · 0 citations

Open access Jul 2026

STING agonists in combination with epigenetic drugs potentiate ZNFX1-driven inflammatory necroptosis in TP53 -mutated AML

TP53-mutated AML potentiates effects of novel next-generation STING agonist C92, with unique allosteric and non-cyclic dinucleotide (non-CD) mechanism of action, inducing increased STING activation and cytokine release STING agonists and DNMTis, synergistically increase STING activation with marked transcriptome-wide i...

K. Tripathi, Lora Stojanovic, Zahra Gohari et al. · bioRxiv · 0 citations