Alyah F. Chmiel

Application of Bioisosteres in the Design and Discovery of FDA-Approved Drugs and Advanced Clinical Candidates.

Since its introduction in 1951, bioisosterism has become a cornerstone strategy in drug design and development, enabling chemists to rationally modify molecular structures to optimize biological and physicochemical properties. In this perspective, we examine 57 FDA-approved drugs and 18 advanced drug candidates wherein...