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Author

Alyssa Jeffrey

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Open access Aug 2026

Mesenchymal drift in ciliopathy iPSC-derived RPE reveals a convergent pathogenic cell state.

This study develops induced pluripotent stem cell-derived RPE models (iRPE) and identifies two drugs, pioglitazone, a mitochondrial metabolic modulator, and galunisertib, a TGFBR1 inhibitor, as potential therapeutic candidates for multiple ciliopathy subtypes.

Dominik Reichert, Sena Gul, D. Ortolan et al. · 0 citations

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