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Exploring the Therapeutic Potential of Chalcones in Alzheimer's Disease: Mechanistic Insights and SAR Perspectives.
Overall, chalcone-based MTDLs provide a rational framework for the development of next-generation anti-Alzheimer agents, highlighting the effects of hydroxylation, methoxylation, halogenation, halogenation, and heterocyclic hybridization on biological activity.
Thiazole-based Small Molecules as Potential Anti-Alzheimer's Agents: SAR and Mechanistic Insights.
This research highlights the feasibility of using thiazole-derived AChE, BuChE, MAO-B, and amyloid-β inhibitors as scaffold pharmacophores for developing novel drugs to treat Alzheimer's disease and provides vital guidance on the development of future drugs.