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Amanda C. Macke

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Open access Sep 2026

Inositol Hexakisphosphate Promotes Open Pore State in HIV Capsid Protein Lattice by Reconfiguring Subunit Contacts

The mature human immunodeficiency virus (HIV-1) capsid is composed of approximately 250 capsid protein hexamers, each containing a central pore delimited by a β-hairpin and an α-helix from each monomer. The cellular metabolite inositol hexakisphosphate (IP6) binds this pore and modulates translocation of nucleoside t...

Y. Knelissen, Judith Escrig, Amanda C. Macke et al. · 0 citations

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