Development of a europium-thiosemicarbazide-based nano-optical biosensor for early detection of HE4 in ovarian cancer.
Early diagnosis of ovarian cancer remains a major clinical challenge. Human epididymis protein 4 (HE4) has emerged as a promising biomarker for early OC detection. To address limitations of existing HE4 quantification methods, we developed a nano-optical biosensor based on a luminescent europium-thiosemicarbazide (Eu-T...