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Author

Amin Safaeesirat

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Open access Sep 2026

Motif-based model of transcription predicts effects of sequence variants in AR enhancers and reveals distinct functions for AR-associated transcription factors

Androgen receptor (AR)-mediated transcription plays a central role in prostate cancer development and progression, yet the contributions of individual transcription factors (TFs) to AR-dependent enhancer activity remain incompletely understood. Here we use a biophysically motivated, interpretable motif-based model to d...

Hoda Taeb, Amin Safaeesirat, Emirhan Tekoglu et al. · 0 citations

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