Amir Amiri Tabat

PeakATail: precision-first poly(A)-site calling and calibrated alternative polyadenylation analysis in single-cell RNA-seq

Most human genes can end their messenger RNAs at more than one position, and the choice shifts between cell types. Single-cell sequencing reads that choice in individual cells, but two questions are seldom asked: are the reported sites real, and does the test for a cell-type difference hold its error rate? Here we intr...