Author

A. Asiaee

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Review Open access Aug 2026

Keystone Epitope Theory: Implications for Hypersensitivity, Autoimmunity, and Transplantation

HLA class I alleles confer a striking risk for T cell–mediated drug hypersensitivity, yet positive predictive values are low—typically under 10% and as low as 0.12% for some drug–HLA pairs. We propose that persistent, human-adapted pathogens—notably herpesviruses—focus postnatal immune memory on conserved epitopes in t...

Simon Mallal, Amir Asiaee, Elizabeth J. Phillips · Pathogens and Immunity · 2 citations

Review Aug 2026

Keystone Epitope Theory: An Ecological Perspective on RNA Viruses, Tumor Immunoediting, and Vaccine Design

3 vaccine design principles are concluded: prioritize epitopes where substitutions carry measurable fitness costs, avoid immunogens dominated by mutable targets, and account for antigen presentation context and inhibitory NK signaling when evaluating epitope choice.

Simon Mallal, Amir Asiaee · Pathogens and Immunity · 3 citations