Mitocurcumin disrupts glutathione balance by modulating Klf9/GSR axis to overcome platinum resistance in non-small cell lung cancer and restores immune surveillance in cold tumor.
Chemoresistance remains a major barrier in non-small cell lung cancer (NSCLC) therapy. Glutathione reductase (GSR), a central regulator of glutathione redox homeostasis, has been implicated in tumor survival, yet its role in non-small cell lung cancer (NSCLC) chemoresistance remains unclear. We demonstrated that GSR is...