Safinamide dual molecular mechanisms: sodium channel and glutamate modulation as a translational rationale for neuropathic pain – A narrative review
Abstract Introduction Neuropathic pain is a chronic and debilitating condition characterized by maladaptive changes in peripheral and central nervous system pathways. It is driven by abnormal neuronal excitability and excitatory neurotransmission. Among the key contributors are voltage-gated sodium channels (VGSCs) and...