Improving the Oral Delivery of Carmustine Via a Self-Microemulsifying Drug Delivery System
Objective: Carmustine (BCNU), a nitrosourea-class chemotherapeutic agent, is extensively utilized in the treatment of high-grade gliomas and brain metastases owing to its efficient penetration across the blood–brain barrier. However, its clinical utility is limited by poor aqueous solubility, rapid degradation, and a s...