Non-alcoholic fatty liver disease (NAFLD) is a common metabolic condition characterized by hepatic steatosis and chronic low-grade inflammation, with oxidative stress playing a pivotal role in its progression. The neutrophil-to-lymphocyte ratio (NLR) has been proposed as an accessible marker reflecting systemic inflamm...
Amr A. El-Sehrawy, Ahmed M. Salah, Ismail Kandil et al.· Scientific Reports· 0 citations
Ischemic stroke and subsequent reperfusion injury are major causes of mortality and long-term neurological disability, driven by complex mechanisms of excitotoxicity, oxidative stress, neuroinflammation, endothelial dysfunction, and blood-brain barrier disruption. Increasing evidence indicates that long non-coding RNA...
Amr A. El-Sehrawy, I. Sapaev, O. Nematov et al.· Clinica chimica acta; intern...· 0 citations
Growing evidence suggests that composite metabolic indices may offer valuable insights into obesity-related complications. The Cardiometabolic Index (CMI), a surrogate marker of adverse lipid profiles and central adiposity, has emerged as a promising indicator of cardiometabolic risk. Nevertheless, its association with...
Amr A. El-Sehrawy, Ismail Kandil, M. Maashi et al.· Scientific Reports· 0 citations
Background The gut microbiota plays an important role in metabolic homeostasis and systemic inflammation, and dietary habits are major determinants of its composition and function. This study investigated the association between adherence to the Dietary Index for Gut Microbiota (DIGM) and cardiometabolic, inflammatory,...
Amr A. El-Sehrawy, Ismail Kandil, Safa Labib et al.· Scientific Reports· 0 citations
Gen silencing studies demonstrate that AEG-1 knockdown reduces proliferation, promotes apoptosis, and enhances sensitivity to chemotherapeutic agents such as cisplatin, doxorubicin, and temozolomide, and support its potential as a target for combinatorial therapeutic strategies to improve outcomes in aggressive brain a...
S. Mohammad, A. Vasudevan, M. Al-Khreisat et al.· Tissue & Cell· 0 citations
In CAR-NK models, Rafei further demonstrated in CAR-NK models that CREM functions as a regulatory checkpoint limiting NK cell cytotoxicity and cytokine production, while its relevance in resting/native NK cells remains to be established.
Amr A. El-Sehrawy, M. Al-Khreisat, Jalpa R. Patel et al.· Cancer Immunology and Immuno...· 0 citations
The global resistome is mapped to map the global resistome, quantify temporal and host-specific trends, and assess the association between genetic determinants and phenotypic resistance by analyzing over 110,000 S. aureus genomes.
Amr A. El-Sehrawy, S. Jasim, Haneen Fadhil Jasim et al.· BMC Microbiology· 0 citations
This review argues that circular topology should be viewed as an active pharmacologic variable, not merely a stability enhancement, and dissect recent advances in cap-independent translation initiation, including IRES elements and m6A-driven mechanisms, rolling-circle translation for multi-epitope vaccine design, and p...
Amr A. El-Sehrawy, H. Al-Ameer, J. Rizaev et al.· Biotechnology and Bioenginee...· 0 citations
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