Amr S. Helmy

Rationale design and synthesis of new quinazoline derivatives as DNA intercalators and topoisomerase II inhibitors.

In pursuit of novel anticancer agents with enhanced potency and selectivity, a new series of quinazoline-based derivatives was rationally designed, synthesized, and biologically evaluated as potential DNA intercalators and topoisomerase II (Topo II) inhibitors. Building upon a previously identified lead compound (6), s...