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Author

Amrutha Kizhedathu

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Open access Sep 2026

A Meiotic B-type Cyclin Selectively Drives Mitotic Progression and Fidelity in Cancer Cells

Cell cycle transitions are driven by cyclins in complex with cyclin-dependent kinases (CDK). Here, we demonstrate that cyclin B3, an evolutionarily divergent B-type cyclin previously thought to function exclusively in female meiosis, is expressed in mitotic cells and interacts with both CDK1 and CDK2. We show that cycl...

Amrutha Kizhedathu, Anh Cao Ngoc Nguyen, Clinton Yu et al. · 0 citations
Open access Jul 2026

Cyclin B3-CDK1 couples translational de-repression to embryonic mitoses via OMA protein degradation in C. elegans

It is established that embryonic activation of the cyclin B3-CDK1 complex drives both mitotic divisions and mRNA de-repression, which ensures that cell division is coupled to the early gene expression program in development.

D. Bojorquez, Shabnam Moghareh, Maab Elsayed et al. · 0 citations

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