Amy J. Gleichman

Astrocytic chordin-like 1 (Chrdl1) is re-engaged early after ischemic stroke to regulate region-dependent GluA2 levels and neuronal vulnerability

Neuronal vulnerability to ischemic stroke varies markedly across brain regions, yet the mechanisms underlying this selective susceptibility remain poorly understood. Here, we show that the developmental astrocytic protein Chordin-like 1 (Chrdl1) is repurposed after ischemic injury to regulate neuronal vulnerability. Ch...