Mass spectrometry (MS)-based proteomics has transformed our ability to measure protein abundance and modification state on a proteome-wide scale. However, many critical determinants of protein function, including post-translational modification (PTM) state, spatial localization, and enzyme activity, require strategies...
Umasankar Mondal, Amy M. Weeks· Current Opinion in Chemical...· 0 citations
It is shown that phage-assisted evolution can be used to rapidly optimize enzymes for the synthesis of noncanonical tyrosine derivatives in Escherichia coli and this platform provides a powerful approach for the rapid engineering of ncAA synthases amenable to use in cells.
James S. Andon, Abhijit Behera, Debashrito Deb et al.· Proceedings of the National...· 0 citations
Protein engineering appears to be entering a golden age, defined by a rapidly accelerating pace of progress, even as significant challenges in design, screening, and real-world application remain.
H. Ai, Frances H. Arnold, Doug Barrick et al.· Protein engineering, design...· 0 citations
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