An-Ran Fu

Discovery and Characterization of Conserved N-Oxide-Forming Function of FAD-Dependent Monooxygenases for Fungal Prenylated Indole Alkaloid Biosynthesis.

N-oxides are ubiquitous functional groups in natural products, conferring critical biological properties such as enhanced solubility and modulated membrane permeability. However, the biosynthetic pathways for N-oxide formation in complex prenylated indole alkaloids (PIAs), especially the penicimutamides, remain poorly...