An-Zhu Bao

Sequential antibody induction for immune tolerance in clinical organ transplantation: a feasibility review of immunosuppressant withdrawal protocols

This review systematically examines the immunological rationale and major clinical strategies (T-cell depletion, costimulation blockade, mixed chimerism, and regulatory cell therapy) and proposes four novel sequential regimens with explicit evidence levels based on efficacy, safety, and feasibility.