Ana de Lucas-Rius

SARS-CoV-2 ORF8 Exploits Host miRNA Networks to Rewire Post-Transcriptional Regulation

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes several accessory proteins that modulate host cellular pathways and contribute to immune evasion and disease severity. Among them, ORF8 has emerged as a key immunomodulatory factor; however, its impact on host post-transcriptional regulatory networks...

SARS-CoV-2 ORF7a drives mitochondrial dysfunction via PDK4 activation and complex I inhibition.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection reprograms host metabolism to favor viral replication and immune evasion, yet the contribution of accessory proteins remains poorly defined. Here, we characterize the metabolic effects of the SARS-CoV-2 accessory protein ORF7a. Lentiviral expression...

A single Omicron mutation reshapes ORF3a-driven host-cell remodelling