Author

Ana Losada

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Open access Sep 2026

The CENP-A chaperone complex spatially organizes centromeres

Centromeres, defined by CENP-A–containing nucleosomes, direct kinetochore assembly for spindle attachment. In mitosis, CENP-A and the constitutive centromere-associated network (CCAN) of the inner kinetochore are arranged into bipartite subdomains within clearings of chromatin. However, less is known about their archit...

Hindol Gupta, Julian Haase, Yi-Cong Wu et al. · Science Advances · 0 citations

Open access Jul 2026

Contribution of cohesins STAG1 and STAG2 to preimplantation development in mice.

Cohesin complexes carrying either STAG1 or STAG2 display functional specificities in both cohesion and genome organization. While any variant is sufficient for cell viability, both are essential for murine embryonic development, and mutations in STAG1 and STAG2 are associated to human syndromes. The requirements and re...

Maria Solé-Ferran, Maria Jose Andreu, D. Giménez-Llorente et al. · Communications Biology · 0 citations