Author

Ana S. Leal

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Open access Aug 2026

Virtual Screening–Guided Identification of Candidate USP7-Inhibitory Scaffolds Exhibiting Antiproliferative Activity

This integrated virtual screening and experimental validation approach enabled the identification of candidate USP7-inhibitory scaffolds with preliminary antiproliferative activity that warrant further medicinal chemistry optimization, orthogonal validation, and mechanistic characterization to establish their potential...

Rita I. Oliveira, C. Franco, M. Mano et al. · Pharmaceuticals · 0 citations

Open access Jul 2026

Treatment Responses Alter Myeloid Activation in BRAF-Mutant Melanoma 2252856

This work establishes for the first time that BRAFi promotes myeloid-mediated induction of T cell activation, which is lost at resistance but can be rescued with the addition of CDDO- me, and provides the foundation for its potential use in combination therapies for melanoma.

Chen-Yu Wang, G. Torres, Helen C. Jarnagin et al. · Journal of Immunology · 0 citations