Attrition adjustment in sample size calculation for Intention-to-treat (ITT)-based clinical trials: Evidence from a clinical trial simulation study.
AIMS Attrition in randomized clinical trials (RCTs) threatens internal validity and reduces statistical power, challenging the integrity of analyses. Different methods to handle missing data such as last observation carried forward (LOCF), multiple imputation (MI) and per-protocol (PP) vary in bias and impact. Whether...