Review
Open access
Jul 2026
SARS-CoV-2 endoribonucleaseU and ORF6 work synergistically to antagonize innate immune signaling 2327626
The synergistic relationship between nsp15 and ORF6 is essential for efficient SARS-CoV-2 replication and it is hypothesized that since nsp15 functions by reducing dsRNA upstream of ORF6, nsp15 acts as a more potent antagonist leaving little activity for ORF6 to account for.
Nicole R. Bracci, Clayton J. Otter, Nicholas A. Parenti et al.
· Journal of Immunology · 0 citations