Open access
Jul 2026
α2δ-1 regulates synaptic AMPA receptor trafficking and LTP through distinct pre- and postsynaptic functions.
This work identifies α2δ-1 as an extracellular AMPAR regulatory protein with distinct pre- and postsynaptic functions: in cis, limiting AMPAR access to synapses; in trans, facilitating LTP.
Gerardo Leana-Sandoval, Matthew A. Sandoval, Ananth V. Kolli et al.
· Neurobiology of Disease · 0 citations