Anas Houlal

POLD1 and Endometrial Cancer: Molecular Mechanisms, Genomic Pathology, and Emerging Therapeutics.

Endometrial cancer (EC) is a major gynecologic malignancy whose classification and treatment paradigms are evolving because of molecular profiling. Mutations in DNA polymerases, particularly in DNA polymerase epsilon (POLE) and DNA polymerase delta 1 (POLD1), have become central to a subset of ultramutated ECs with cru...