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Anas J. Rasras

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Open access Oct 2026

3,4-Dihydropyrimidin-2(1H)-one Hybrids as Phenotypic Anti-Breast Cancer Agents: Synthesis, Colony-Formation Profiling and Computational Target Deconvolution

3,4-Dihydropyrimidin-2(1H)-ones (DHPMs) are privileged heterocyclic scaffolds with broad biological activities. Sixteen DHPM hybrids (4a–p) carrying para- or ortho-aryloxy linkers and diverse terminal amines were prepared through a modular propargylation, Mannich-type, and Biginelli sequence. The compounds were ranked...

Hadeel D. Sultan, Rocco Buccheri, Anas J. Rasras et al. · 0 citations

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