It is demonstrated that heterologous DNA/rAd5 vaccination generates antigen-specific CD8⁺ T cell memory with distinct clonal trajectories and cellular programs, providing new insights into how vaccine platform and antigen-specificity shape the durability and functional properties of HIV-1 specific cellular immunity.
Summary Background Human pregnancy presents a unique physiological state that allows for growth of an antigenically dissimilar foetus. The immune system plays a key role in establishing and maintaining successful pregnancy, yet detailed understanding of immunological responses in pregnancy is lacking. Methods We define...
Jennifer R. Habel, Thi H. O. Nguyen, L. Allen et al.· EBioMedicine· 0 citations
Combinatorial pairing of independently recombined T cell receptor (TCR) α- and β-chains is central to diversifying the TCR repertoire. Although sequence motifs in one chain correlate with epitope recognition, the extent to which a single chain dictates specificity remains unclear. Here, we systematically tested TCR cha...
Anastasia A. Minervina, M. Pogorelyy, K. Mayer-Blackwell et al.· Science· 0 citations
CopepodTCR enables efficient and accurate mapping of TCR—peptide specificities through optimized combinatorial peptide pooling coupled with Bayesian inference.
V. Kovaleva, David J Pattinson, Guanchen He et al.· Journal of Immunology· 0 citations
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