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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Ancheng Shen

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2 papers indexed here

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Oct 2026

Design and discovery of highly potent lysine 27 of histone H3 (H3K27) demethylase inhibitors for the treatment of inflammatory bowel disease.

Lysine specific demethylase 6A/B (KDM6A/B), histone lysine demethylases targeting H3K27me3, have emerged as key regulators of inflammatory gene expression and are increasingly implicated in the pathogenesis of inflammatory bowel disease (IBD). However, there remains a critical need for potent, selective, and cell-activ...

Yu-Qi Tang, Xin Hu, An-Cheng Shen et al. · 0 citations
Jul 2026

Discovery of Thiazolo[5,4-c]pyridine Derivatives as Novel Hematopoietic Progenitor Kinase 1 Inhibitors for Tumor Immunotherapy.

This new inhibitor exhibits potent HPK1 inhibition, high selectivity within the MAP4K family, along with improved metabolic properties and reduced hERG liability, and demonstrates robust monotherapy efficacy and synergizes with an anti-PD-1 antibody or an anti-PD-L1/IL-15 immunocytokine prodrug.

Ying Wang, Ye Yang, Yi-Ming Yu et al. · 0 citations

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