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Cervical lymphadenectomy impairs brain lymphatic clearance and synaptic proteostasis.
Meningeal lymphatic vessels drain brain fluid and waste into the cervical lymph nodes, but how removing these nodes during surgery affects brain health is unknown. Retrospective analysis of cancer patients who underwent neck lymphadenectomy without chemo-radiation therapy found that up to 25% developed mild-to-severe c...
Myeloid reprogramming generates myeloid-derived activating cells to potentiate radiotherapy and suppress metastasis.
These findings define MDACs as an immunogenic myeloid subset and establish myeloid reprogramming as a strategy to improve radiotherapy-immunotherapy outcomes.