Open access
Jul 2026
GDF15 modulates mitochondrial content and differentiation-associated metabolic remodeling in skeletal muscle cells.
It is demonstrated that GDF15 promotes an oxidative phenotype in skeletal muscle cells through PGC1α-dependent activation of PPAR and ERRα, identifying GDF15 as an autocrine regulator of mitochondrial metabolism and muscle adaptation.
B. C. Favero-Santos, Carolina M. Lazaro, Jung Tae Kim et al.
· American Journal of Physiolo... · 0 citations