Andrea Esposito

Phase separation of ecDNA condensates establishes in-trans contact domains that boost selective MYC regulatory interactions

Extrachromosomal DNAs (ecDNAs) are circular DNA elements found in many human cancers, often carrying oncogenes and regulatory elements. In COLO320-DM colorectal cancer cells, MYC-harboring ecDNAs form nuclear clusters associated with oncogene overexpression, but the mechanisms underlying their aggregation and gene upre...