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Author

Andrea J. Tenner

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Review Open access Aug 2026

Complement-dependent phagocytosis in the clearance of various cellular targets.

Phagocytosis is the process of recognition and uptake of cells or large cellular debris; this process contributes to the removal of pathogens, cancerous cells and dead cells from the human body. Phagocytosis is greatly enhanced by the deposition of opsonins on the target cells, which act as a bridge between the target...

M. Blanter, Max L. B. Grönloh, P. E. Marques et al. · 0 citations
Open access Jul 2026

Young Adult Microglial Deletion of C1q Reduces Engulfment of Synapses and Partially Mitigates Cognitive Impairment in an Aggressive Alzheimer's Disease Mouse Model

C1q is a multifunctional protein, including its role as the initiating protein of the classical complement cascade. While classical pathway activation is involved in synaptic pruning during nervous system development, it also contributes to inflammation and cognitive decline in Alzheimer's disease (AD). Constitutive ge...

Tiffany J. Petrisko, Shu-Hui Chu, Angela Gomez-Arboledas et al. · 1 citation

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