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Author

Andreas Carlsson

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Open access Sep 2026

DNAJB6b — a complete amyloid inhibitor

In Alzheimer’s disease (AD), the aggregation of amyloid β (Aβ) peptides has been linked to disease pathology. Once aggregates have formed, existing fibrils catalyze the formation of new fibrils in a runaway process associated with neuro degeneration. One component of the cellular defense system against amyloid formatio...

Andreas Carlsson, U. Olsson, S. Linse · 0 citations
Open access Aug 2026

Human chaperone DNAJB6b suppresses tau fibril formation through co-aggregation

The authors study the impact of DNAJB6b on tau fibril formation, showing that it delays tau aggregation by co-assembling with small tau aggregates and by binding to mature fibrils, reducing their ability to catalyze further fibril growth.

Andreas Carlsson, Emil Axell, Johan Wallerstein et al. · 1 citation · ⚡1

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