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Andrew C. Dixson

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Open access Aug 2026

PKR engages viral RNA and intron-retained host transcripts during poxvirus infection.

Recognition of double-stranded (ds) RNA is central to antiviral defense, yet how RNA sensors are activated during infection remains unclear. Here, we demonstrate that during vaccinia virus (VacV) infection, PKR binding is enriched on viral RNAs and host-intron-containing transcripts. During infection, RNase L activatio...

Rui-Lin Zhang, Xiang Ye, Andrew C. Dixson et al. · 0 citations

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