Author

Andrew C. Kruse

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Open access Sep 2026

GPCR antagonism via rewiring of receptor trafficking and degradation

G protein–coupled receptors (GPCRs) represent one of the most important yet incompletely addressed classes of therapeutic targets1. Here, we report a novel strategy for functional GPCR antagonism via bispecific antibody-mediated endocytosis and lysosomal degradation. GPCR-TfR1 targeting chimeras (GTACs) achieve potent...

Kaitlin Rhee, L. Shue, Akimasa Adachi et al. · Nature · 0 citations

Sep 2026

Multifunctional antibody responses from a primate Shigella outbreak inform vaccine design.

There is currently no approved vaccine for Shigella spp., a leading cause of diarrhea with increasing rates of antimicrobial resistance. Shigella vaccine development is complicated in part by an incomplete understanding of the structural and molecular determinants of immunity. To address this, we isolated monoclonal an...

Robert M. Gallant, Paul Savarino, Sophia Pulido et al. · Science Translational Medici... · 0 citations

Open access Aug 2026

Structural basis for nutrient-activated channel opening in bacterial spore germination receptors

GerA-family germinant receptors were recently identified as ion channels that initiate germination of dormant bacterial spores in response to nutrients. Here we report 2.0-Å cryo-electron microscopy structures of apo, agonist-bound, and antagonist-bound GerA, revealing a symmetric pentamer of heterotrimers. Signaling r...

Joshua C. Cofsky, Fernando H. Ramírez-Guadiana, Briana L. Sobecks-Doherty et al. · bioRxiv · 0 citations

Open access Sep 2026

Structural basis for tetraspanin-dependent surface export and adhesive function of integrin α3β1

Integrin α3β1 (ITGα3β1) is a member of an integrin subfamily that binds to laminin proteins and promotes attachment of epithelial cells to the basement membrane. ITGα3β1 forms a complex with the tetraspanin CD151, and loss-of-function mutations in both ITGα3 and CD151 cause epidermolysis bullosa, a severe skin blisteri...

L. Litzau, Elizabeth K. Wren, Andrew C. Kruse et al. · bioRxiv · 0 citations

Open access Aug 2026

Profiling Protein‐Peptide Interactions by Yeast Surface Display

A protocol for discovering protein‐binding peptides using a very large, target‐agnostic yeast surface display library containing approximately 6.1 × 109 unique clones and providing broad coverage of short peptide sequence space is described.

J. D. Hurley, Andrew C. Kruse · Current Protocols · 0 citations